Host: |
Rabbit |
Applications: |
WB/IF |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-GRM5 (870-1212) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
GRM5 |
Gene ID: |
2915 |
Uniprot ID: |
GRM5_HUMAN |
Immunogen Region: |
870-1212 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 870-1212 of human GRM5 (NP_001137303.1). |
Immunogen Sequence: |
GSSGETLRYKDRRLAQHKSE IECFTPKGSMGNGGRATMSS SNGKSVTWAQNEKSSRGQHL WQRLSIHINKKENPNQTAVI KPFPKSTESRGLGAGAGAGG SAGGVGATGGAGCAGAGPGG PESPDAGPKALYDVAEAEEH FPAPARPRSPSPISTLSHRA GSASRTDDDVPSLHSEPVAR SSSSQGSLMEQISSVVTRFT A |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
Protein Name | Metabotropic Glutamate Receptor 5Mglur5 |
Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 5 antibodyAnti-Mglur5 antibodyAnti-GRM5 antibodyAnti-GPRC1E antibodyAnti-MGLUR5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance