Anti-GRM4 antibody (33-290) (STJ29423)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GRM4 (33-290) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRM4 |
| Gene ID | 2914 |
| Uniprot ID | GRM4_HUMAN |
| Immunogen Region | 33-290 |
| Immunogen Sequence | KPKGHPHMNSIRIDGDITLG GLFPVHGRGSEGKPCGELKK EKGIHRLEAMLFALDRINND PDLLPNITLGARILDTCSRD THALEQSLTFVQALIEKDGT EVRCGSGGPPIITKPERVVG VIGASGSSVSIMVANILRLF KIPQISYASTAPDLSDNSRY DFFSRVVPSDTYQAQAMVDI VRALKWNYVSTVASEGSYGE SGVEAFIQKSREDGGVCIAQ SVKIPREPKAGEFDKIIRR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1). |
Additional Info
| Tissue Specificity | Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. |
| Protein Name | Metabotropic Glutamate Receptor 4Mglur4 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 4 antibodyAnti-Mglur4 antibodyAnti-GRM4 antibodyAnti-GPRC1D antibodyAnti-MGLUR4 antibody |
Information sourced from Uniprot.org