| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRM4 |
| Gene ID: | 2914 |
| Uniprot ID: | GRM4_HUMAN |
| Immunogen Region: | 33-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1). |
| Immunogen Sequence: | KPKGHPHMNSIRIDGDITLG GLFPVHGRGSEGKPCGELKK EKGIHRLEAMLFALDRINND PDLLPNITLGARILDTCSRD THALEQSLTFVQALIEKDGT EVRCGSGGPPIITKPERVVG VIGASGSSVSIMVANILRLF KIPQISYASTAPDLSDNSRY DFFSRVVPSDTYQAQAMVDI VRALKWNYVSTVASEGSYGE SGVEAFIQKSREDGGVCIAQ SVKIPREPKAGEFDKIIRR |
| Tissue Specificity | Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. |
| Protein Name | Metabotropic Glutamate Receptor 4 Mglur4 |
| Database Links | Reactome: R-HSA-418594 Reactome: R-HSA-420499 Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 4 antibody Anti-Mglur4 antibody Anti-GRM4 antibody Anti-GPRC1D antibody Anti-MGLUR4 antibody |
Information sourced from Uniprot.org