• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-GRK4 antibody (10-90 aa) (STJ93434)

SKU:
STJ93434

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-G protein-coupled receptor kinase 4 (10-90 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRK4
Gene ID: 2868
Uniprot ID: GRK4_HUMAN
Immunogen Region: 10-90 aa
Specificity: GRK 4 Polyclonal Antibody detects endogenous levels of GRK 4 protein.
Immunogen: Synthesized peptide derived from GRK 4 at the amino acid range 10-90
Post Translational Modifications Palmitoylated.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin.the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Protein Name G Protein-Coupled Receptor Kinase 4
G Protein-Coupled Receptor Kinase Grk4
Iti1
Database Links Reactome: R-HSA-2514859 P32298-1
Cellular Localisation Cytoplasm
Cell Cortex
Both At The Cell Surface And Dispersed In The Cytoplasm Under Basal Conditions
Receptor Stimulation Results In The Internalization Of Grk4 To The Perinuclear Area
Where Colocalization With Drd3 Is Observed Strongly At 5 And 15 Minutes
Drd3 And Grk4 Colocalize In Lipid Rafts Of Renal Proximal Tubule Cells
Alternative Antibody Names Anti-G Protein-Coupled Receptor Kinase 4 antibody
Anti-G Protein-Coupled Receptor Kinase Grk4 antibody
Anti-Iti1 antibody
Anti-GRK4 antibody
Anti-GPRK2L antibody
Anti-GPRK4 antibody

Information sourced from Uniprot.org

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