Anti-GRK4 antibody (10-90 aa) (STJ93434)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from GRK 4 at the amino acid range 10-90
General Information
| Short Description | Rabbit polyclonal anti-G protein-coupled receptor kinase 4 (10-90 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRK4 |
| Gene ID | 2868 |
| Uniprot ID | GRK4_HUMAN |
| Immunogen | Synthesized peptide derived from GRK 4 at the amino acid range 10-90 |
| Immunogen Region | 10-90 aa |
| Specificity | GRK 4 Polyclonal Antibody detects endogenous levels of GRK 4 protein. |
Additional Info
| Post Translational Modifications | Palmitoylated. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin.the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |
| Protein Name | G Protein-Coupled Receptor Kinase 4G Protein-Coupled Receptor Kinase Grk4Iti1 |
| Database Links | Reactome: R-HSA-2514859 P32298-1 |
| Cellular Localisation | CytoplasmCell CortexBoth At The Cell Surface And Dispersed In The Cytoplasm Under Basal ConditionsReceptor Stimulation Results In The Internalization Of Grk4 To The Perinuclear AreaWhere Colocalization With Drd3 Is Observed Strongly At 5 And 15 MinutesDrd3 And Grk4 Colocalize In Lipid Rafts Of Renal Proximal Tubule Cells |
| Alternative Antibody Names | Anti-G Protein-Coupled Receptor Kinase 4 antibodyAnti-G Protein-Coupled Receptor Kinase Grk4 antibodyAnti-Iti1 antibodyAnti-GRK4 antibodyAnti-GPRK2L antibodyAnti-GPRK4 antibody |
Information sourced from Uniprot.org