| Short Description : | Rabbit polyclonal GRIP1 (1-1061) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRIP1 |
| Gene ID: | 23426 |
| Uniprot ID: | GRIP1_HUMAN |
| Immunogen Region: | 1-1061 |
| Immunogen Sequence: | MIAVSFKCRCQILRRLTKDE SPYTKSASQTKPPDGALAVR RQSIPEEFKGSTVVELMKKE GTTLGLTVSGGIDKDGKPRV SNLRQGGIAARSDQLDVGDY IKAVNGINLAKFRHDEIISL LKNVGERVVLEVEYELPPVS VQGSSVIFRTVEVTLHKEGN TFGFVIRGGAHDDRNKSRPV VITCVRPGGPADREGTIKPG DRLLSVDGIRLLGTTHAEAM SILKQCGQEAALLIEYDVS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GRIP1 (NP_001171545.1). |
| Function | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. |
| Protein Name | Glutamate Receptor-Interacting Protein 1Grip-1 |
| Database Links | Reactome: R-HSA-416993 |
| Cellular Localisation | Cytoplasmic VesiclePerikaryonCell ProjectionDendriteCytoplasmEndomembrane SystemPeripheral Membrane ProteinPostsynaptic Cell MembranePostsynaptic DensityEndoplasmic Reticulum MembraneMembrane-Associated With VesiclesPeri-Golgi Complexes And Endoplasmic ReticulumEnriched In Postsynaptic Plasma Membrane And Postsynaptic Densities |
| Alternative Antibody Names | Anti-Glutamate Receptor-Interacting Protein 1 antibodyAnti-Grip-1 antibodyAnti-GRIP1 antibody |
Information sourced from Uniprot.org
