| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRIA3 (200-490) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIA3 |
| Gene ID: |
2892 |
| Uniprot ID: |
GRIA3_HUMAN |
| Immunogen Region: |
200-490 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3). |
| Immunogen Sequence: |
QEFRRIIEEMDRRQEKRYLI DCEVERINTILEQVVILGKH SRGYHYMLANLGFTDILLER VMHGGANITGFQIVNNENPM VQQFIQRWVRLDEREFPEAK NAPLKYTSALTHDAILVIAE AFRYLRRQRVDVSRRGSAGD CLANPAVPWSQGIDIERALK MVQVQGMTGNIQFDTYGRRT NYTIDVYEMKVSGSRKAGYW NEYERFVPFSDQQISNDSAS SENRTIVVTTILESPYVMY |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 3Glur-3Ampa-Selective Glutamate Receptor 3Glur-CGlur-K3Glutamate Receptor Ionotropic - Ampa 3Glua3 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneInteraction With Cnih2 And Cnih3 Promotes Cell Surface Expression |
| Alternative Antibody Names | Anti-Glutamate Receptor 3 antibodyAnti-Glur-3 antibodyAnti-Ampa-Selective Glutamate Receptor 3 antibodyAnti-Glur-C antibodyAnti-Glur-K3 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 3 antibodyAnti-Glua3 antibodyAnti-GRIA3 antibodyAnti-GLUR3 antibodyAnti-GLURC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
