Anti-Granzyme A antibody [GA6] (STJ16100861)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant human Granzyme A.
General Information
| Short Description | Mouse monoclonal anti-Granzyme A for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | GA6 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1.0 mg/mL |
| Formulation | PBS with 0.09% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | GZMA |
| Gene ID | 3001 |
| Uniprot ID | GRAA_HUMAN |
| Immunogen | Recombinant human Granzyme A. |
Additional Info
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Protein Name | Granzyme ACtl TryptaseCytotoxic T-Lymphocyte Proteinase 1Fragmentin-1Granzyme-1Hanukkah FactorH FactorHf |
| Database Links | |
| Cellular Localisation | Isoform Alpha: SecretedCytoplasmic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme A antibodyAnti-Ctl Tryptase antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 1 antibodyAnti-Fragmentin-1 antibodyAnti-Granzyme-1 antibodyAnti-Hanukkah Factor antibodyAnti-H Factor antibodyAnti-Hf antibodyAnti-GZMA antibodyAnti-CTLA3 antibodyAnti-HFSP antibody |
Information sourced from Uniprot.org