| Host: |
Mouse |
| Applications: |
WB/IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Granzyme A is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
GA6 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 0.09% sodium azide |
| Concentration: |
1.0 mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
GZMA |
| Gene ID: |
3001 |
| Uniprot ID: |
GRAA_HUMAN |
| Immunogen: |
Recombinant human Granzyme A. |
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Protein Name | Granzyme ACtl TryptaseCytotoxic T-Lymphocyte Proteinase 1Fragmentin-1Granzyme-1Hanukkah FactorH FactorHf |
| Cellular Localisation | Isoform Alpha: SecretedCytoplasmic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme A antibodyAnti-Ctl Tryptase antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 1 antibodyAnti-Fragmentin-1 antibodyAnti-Granzyme-1 antibodyAnti-Hanukkah Factor antibodyAnti-H Factor antibodyAnti-Hf antibodyAnti-GZMA antibodyAnti-CTLA3 antibodyAnti-HFSP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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