| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPRC6A (300-590) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPRC6A |
| Gene ID: |
222545 |
| Uniprot ID: |
GPC6A_HUMAN |
| Immunogen Region: |
300-590 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human GPRC6A (NP_683766.2). |
| Immunogen Sequence: |
IASDNWSTATKITTIPNVKK IGKVVGFAFRRGNISSFHSF LQNLHLLPSDSHKLLHEYAM HLSACAYVKDTDLSQCIFNH SQRTLAYKANKAIERNFVMR NDFLWDYAEPGLIHSIQLAV FALGYAIRDLCQARDCQNPN AFQPWELLGVLKNVTFTDGW NSFHFDAHGDLNTGYDVVLW KEINGHMTVTKMAEYDLQND VFIIPDQETKNEFRNLKQIQ SKCSKECSPGQMKKTTRSQ |
| Tissue Specificity | Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. |
| Function | Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations. Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. |
| Protein Name | G-Protein Coupled Receptor Family C Group 6 Member AHgprc6aG-Protein Coupled Receptor Gpcr33Hgpcr33 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor Family C Group 6 Member A antibodyAnti-Hgprc6a antibodyAnti-G-Protein Coupled Receptor Gpcr33 antibodyAnti-Hgpcr33 antibodyAnti-GPRC6A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
