Anti-GPRC6A antibody (471-520 aa) (STJ93405)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPRC6A at the amino acid range 471-520
General Information
| Short Description | Rabbit polyclonal anti-G-protein coupled receptor family C group 6 member A (471-520 aa) for use in WB, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPRC6A |
| Gene ID | 222545 |
| Uniprot ID | GPC6A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPRC6A at the amino acid range 471-520 |
| Immunogen Region | 471-520 aa |
| Specificity | GPRC6A Polyclonal Antibody detects endogenous levels of GPRC6A protein. |
Additional Info
| Function | Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations. Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. |
| Protein Name | G-Protein Coupled Receptor Family C Group 6 Member AHgprc6aG-Protein Coupled Receptor Gpcr33Hgpcr33 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor Family C Group 6 Member A antibodyAnti-Hgprc6a antibodyAnti-G-Protein Coupled Receptor Gpcr33 antibodyAnti-Hgpcr33 antibodyAnti-GPRC6A antibody |
Information sourced from Uniprot.org