Anti-GPRC5A antibody (140-189 aa) (STJ95360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPRC5A at the amino acid range 140-189
General Information
| Short Description | Rabbit polyclonal anti-Retinoic acid-induced protein 3 (140-189 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPRC5A |
| Gene ID | 9052 |
| Uniprot ID | RAI3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPRC5A at the amino acid range 140-189 |
| Immunogen Region | 140-189 aa |
| Specificity | RAI3 Polyclonal Antibody detects endogenous levels of RAI3 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3G-Protein Coupled Receptor Family C Group 5 Member APhorbol Ester Induced Gene 1Peig-1Retinoic Acid-Induced Gene 1 ProteinRaig-1 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLocalized In Perinuclear VesiclesProbably Golgi-Associated Vesicles |
| Alternative Antibody Names | Anti-Retinoic Acid-Induced Protein 3 antibodyAnti-G-Protein Coupled Receptor Family C Group 5 Member A antibodyAnti-Phorbol Ester Induced Gene 1 antibodyAnti-Peig-1 antibodyAnti-Retinoic Acid-Induced Gene 1 Protein antibodyAnti-Raig-1 antibodyAnti-GPRC5A antibodyAnti-GPCR5A antibodyAnti-RAI3 antibodyAnti-RAIG1 antibody |
Information sourced from Uniprot.org