| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Retinoic acid-induced protein 3 (140-189 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPRC5A |
| Gene ID: | 9052 |
| Uniprot ID: | RAI3_HUMAN |
| Immunogen Region: | 140-189 aa |
| Specificity: | RAI3 Polyclonal Antibody detects endogenous levels of RAI3 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPRC5A at the amino acid range 140-189 |
| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3 G-Protein Coupled Receptor Family C Group 5 Member A Phorbol Ester Induced Gene 1 Peig-1 Retinoic Acid-Induced Gene 1 Protein Raig-1 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Membrane Localized In Perinuclear Vesicles Probably Golgi-Associated Vesicles |
| Alternative Antibody Names | Anti-Retinoic Acid-Induced Protein 3 antibody Anti-G-Protein Coupled Receptor Family C Group 5 Member A antibody Anti-Phorbol Ester Induced Gene 1 antibody Anti-Peig-1 antibody Anti-Retinoic Acid-Induced Gene 1 Protein antibody Anti-Raig-1 antibody Anti-GPRC5A antibody Anti-GPCR5A antibody Anti-RAI3 antibody Anti-RAIG1 antibody |
Information sourced from Uniprot.org