| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPR68 (276-365) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR68 |
| Gene ID: |
8111 |
| Uniprot ID: |
OGR1_HUMAN |
| Immunogen Region: |
276-365 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3). |
| Immunogen Sequence: |
SFNCVADPVLYCFVSETTHR DLARLRGACLAFLTCSRTGR AREAYPLGAPEASGKSGAQG EEPELLTKLHPAFQTPNSPG SGGFPTGRLA |
| Tissue Specificity | Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. |
| Function | Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer. |
| Protein Name | Ovarian Cancer G-Protein Coupled Receptor 1Ogr-1G-Protein Coupled Receptor 68Gpr12aSphingosylphosphorylcholine Receptor |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ovarian Cancer G-Protein Coupled Receptor 1 antibodyAnti-Ogr-1 antibodyAnti-G-Protein Coupled Receptor 68 antibodyAnti-Gpr12a antibodyAnti-Sphingosylphosphorylcholine Receptor antibodyAnti-GPR68 antibodyAnti-OGR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
