• Western blot analysis of extracts from rat stomach, using M6A Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-GPM6A antibody (140-220 aa) (STJ96409)

SKU:
STJ96409

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neuronal membrane glycoprotein M6-a (140-220 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPM6A
Gene ID: 2823
Uniprot ID: GPM6A_HUMAN
Immunogen Region: 140-220 aa
Specificity: M6A Polyclonal Antibody detects endogenous levels of M6A protein.
Immunogen: Synthesized peptide derived from M6A at the amino acid range 140-220
Function Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs).enhances internalization and recycling of mu-type opioid receptor.
Protein Name Neuronal Membrane Glycoprotein M6-A
M6a
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Axon
Growth Cone
Dendritic Spine
Filopodium
Neuron Projection
Localizes To Cholesterol-Rich Lipid Rafts Of The Plasma Membrane Of Hippocampal Neurons
Localized To Plasma Membrane Of Cell Bodies And Neurites Of Hippocampal Neurons
Localized In Membrane Protrusions (Filopodia And Spines) Of Primary Hippocampal Neurons
Localized To The Growth Cone Edge Membrane Of Elongating Axons
Alternative Antibody Names Anti-Neuronal Membrane Glycoprotein M6-A antibody
Anti-M6a antibody
Anti-GPM6A antibody
Anti-M6A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance