| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Neuronal membrane glycoprotein M6-a (140-220 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPM6A |
| Gene ID: | 2823 |
| Uniprot ID: | GPM6A_HUMAN |
| Immunogen Region: | 140-220 aa |
| Specificity: | M6A Polyclonal Antibody detects endogenous levels of M6A protein. |
| Immunogen: | Synthesized peptide derived from M6A at the amino acid range 140-220 |
| Function | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs).enhances internalization and recycling of mu-type opioid receptor. |
| Protein Name | Neuronal Membrane Glycoprotein M6-A M6a |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Axon Growth Cone Dendritic Spine Filopodium Neuron Projection Localizes To Cholesterol-Rich Lipid Rafts Of The Plasma Membrane Of Hippocampal Neurons Localized To Plasma Membrane Of Cell Bodies And Neurites Of Hippocampal Neurons Localized In Membrane Protrusions (Filopodia And Spines) Of Primary Hippocampal Neurons Localized To The Growth Cone Edge Membrane Of Elongating Axons |
| Alternative Antibody Names | Anti-Neuronal Membrane Glycoprotein M6-A antibody Anti-M6a antibody Anti-GPM6A antibody Anti-M6A antibody |
Information sourced from Uniprot.org