| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPC6 |
| Gene ID: | 10082 |
| Uniprot ID: | GPC6_HUMAN |
| Immunogen Region: | 320-530 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-530 of human GPC6 (NP_005699.1). |
| Immunogen Sequence: | SEAIMNMQENSMQVSAKVFQ GCGQPKPAPALRSARSAPEN FNTRFRPYNPEERPTTAAGT SLDRLVTDIKEKLKLSKKVW SALPYTICKDESVTAGTSNE EECWNGHSKARYLPEIMNDG LTNQINNPEVDVDITRPDTF IRQQIMALRVMTNKLKNAYN GNDVNFQDTSDESSGSGSGS GCMDDVCPTEFEFVTTEAPA VDPDRREVDSS |
| Tissue Specificity | Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level). |
| Function | Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling. |
| Protein Name | Glypican-6 Cleaved Into - Secreted Glypican-6 |
| Database Links | Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Extracellular Side Secreted Glypican-6: Secreted Extracellular Space |
| Alternative Antibody Names | Anti-Glypican-6 Cleaved Into - Secreted Glypican-6 antibody Anti-GPC6 antibody Anti-UNQ369 antibody Anti-PRO705 antibody |
Information sourced from Uniprot.org