• STJ73628 (1µg/ml) staining of Daudi cell lysate (A) + peptide (B) (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ73628 (1µg/ml) staining of Mouse Spleen lysate (A) + peptide (B) (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-GP91-PHOX/NOX2 antibody (Internal) (STJ73628)

SKU:
STJ73628-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-GP91-PHOX/NOX2 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CYBB
Gene ID: 1536
Uniprot ID: CY24B_HUMAN
Immunogen Region: Internal
Accession Number: NP_000388.2
Immunogen Sequence: CDKQEFQDAWKLPK
Post Translational Modifications Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Protein Name Cytochrome B-245 Heavy Chain
Cgd91-Phox
Cytochrome B(558 Subunit Beta
Cytochrome B558 Subunit Beta
Heme-Binding Membrane Glycoprotein Gp91phox
Nadph Oxidase 2
Neutrophil Cytochrome B 91 Kda Polypeptide
Superoxide-Generating Nadph Oxidase Heavy Chain Subunit
Gp91-1
Gp91-Phox
P22 Phagocyte B-Cytochrome
Database Links Reactome: R-HSA-1222556
Reactome: R-HSA-1236973
Reactome: R-HSA-3299685
Reactome: R-HSA-4420097
Reactome: R-HSA-5668599
Reactome: R-HSA-6798695
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
As Unassembled Monomer May Localize To The Endoplasmic Reticulum
Alternative Antibody Names Anti-Cytochrome B-245 Heavy Chain antibody
Anti-Cgd91-Phox antibody
Anti-Cytochrome B(558 Subunit Beta antibody
Anti-Cytochrome B558 Subunit Beta antibody
Anti-Heme-Binding Membrane Glycoprotein Gp91phox antibody
Anti-Nadph Oxidase 2 antibody
Anti-Neutrophil Cytochrome B 91 Kda Polypeptide antibody
Anti-Superoxide-Generating Nadph Oxidase Heavy Chain Subunit antibody
Anti-Gp91-1 antibody
Anti-Gp91-Phox antibody
Anti-P22 Phagocyte B-Cytochrome antibody
Anti-CYBB antibody
Anti-NOX2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance