Anti-GP2 nanobody [SAA1240] (STJN000237)

Anti-GP2 nanobody [SAA1240] (STJN000237)

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STJN000237
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Short Description :Alpaca monoclonal nanobody anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 is suitable for use in ELISA, Immunofluorescence and SPR research applications.
Applications:ELISA/IF/SPR
Host:Alpaca
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA1240
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:GP2
Gene ID:2813
Uniprot ID:GP2_HUMAN
Post Translational Modifications N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH.
Function Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
Protein Name Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2
Pancreatic Zymogen Granule Membrane Protein Gp-2
Zap75
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-9925561
Cellular Localisation Zymogen Granule Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Cell Membrane
Apical Cell Membrane
Membrane Raft
Endosome
After Cleavage
In The Pancreatic Juice
Alternative Nanobody Names Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 nanobody
Anti-Pancreatic Zymogen Granule Membrane Protein Gp-2 nanobody
Anti-Zap75 nanobody
Anti-GP2 nanobody

Information sourced from Uniprot.org

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