Anti-GP2 nanobody [SAA1240] (STJN000237)

Anti-GP2 nanobody [SAA1240] (STJN000237)

SKU:
STJN000237
£378.50 - £1,632.50
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA/IF/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 is suitable for use in ELISA, Immunofluorescence and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1240
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: GP2
Gene ID: 2813
Uniprot ID: GP2_HUMAN
Post Translational Modifications N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH.
Function Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
Protein Name Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2
Pancreatic Zymogen Granule Membrane Protein Gp-2
Zap75
Database Links Reactome: R-HSA-163125
Cellular Localisation Zymogen Granule Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Cell Membrane
Apical Cell Membrane
Membrane Raft
Endosome
After Cleavage
In The Pancreatic Juice
Alternative Nanobody Names Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 nanobody
Anti-Pancreatic Zymogen Granule Membrane Protein Gp-2 nanobody
Anti-Zap75 nanobody
Anti-GP2 nanobody

Information sourced from Uniprot.org

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