Glutaminase antibody immunocytochemistry A549 cells STJA0034370

Anti-Glutaminase antibody [R08-3D8] (STJA0034370)

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STJA0034370
€160.20 - €337.80
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Short Description :Rabbit monoclonal anti-Glutaminase for use in WB, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ICC/IF/IP
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R08-3D8
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.3 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
IF 1:50-1:200
IP 1:20
Formulation:50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:GLS
Gene ID:2744
Uniprot ID:GLSK_HUMAN
Immunogen:Recombinant protein of human Glutaminase C
Tissue Specificity Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle.
Post Translational Modifications Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits.
Function Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Isoform 2: Lacks catalytic activity.
Protein Name Glutaminase Kidney Isoform - Mitochondrial
Gls
K-Glutaminase
L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain
Database Links Reactome: R-HSA-210500
Reactome: R-HSA-5628897
Reactome: R-HSA-8964539
Cellular Localisation Isoform 1: Mitochondrion
Cytoplasm
Cytosol
The 74-Kda Cytosolic Precursor Is Translocated Into The Mitochondria And Processed Via A 72-Kda Intermediate To Yield The Mature 68- And 65-Kda Subunits
Isoform 3: Mitochondrion
Glutaminase Kidney Isoform
Mitochondrial 68 Kda Chain: Mitochondrion Matrix
Produced By The Proteolytic Processing Of The 74-Kda Cytosolic Precursor
Mitochondrial 65 Kda Chain: Mitochondrion Matrix
Alternative Antibody Names Anti-Glutaminase Kidney Isoform - Mitochondrial antibody
Anti-Gls antibody
Anti-K-Glutaminase antibody
Anti-L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain antibody
Anti-GLS antibody
Anti-GLS1 antibody
Anti-KIAA0838 antibody

Information sourced from Uniprot.org

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