| Short Description : | Rabbit polyclonal GIF (20-300) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBLIF |
| Gene ID: | 2694 |
| Uniprot ID: | IF_HUMAN |
| Immunogen Region: | 20-300 |
| Immunogen Sequence: | TQTQSSCSVPSAQEPLVNGI QVLMENSVTSSAYPNPSILI AMNLAGAYNLKAQKLLTYQL MSSDNNDLTIGQLGLTIMAL TSSCRDPGDKVSILQRQMEN WAPSSPNAEASAFYGPSLAI LALCQKNSEATLPIAVRFAK TLLANSSPFNVDTGAMATLA LTCMYNKIPVGSEEGYRSLF GQVLKDIVEKISMKIKDNGI IGDIYSTGLAMQALSVTPEP SKKEWNCKKTTDMILNEIK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human GIF (NP_005133.2). |
| Tissue Specificity | Gastric mucosa. |
| Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
| Protein Name | Cobalamin Binding Intrinsic FactorGastric Intrinsic FactorIntrinsic FactorIfInf |
| Database Links | Reactome: R-HSA-3359457Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-9758881 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cobalamin Binding Intrinsic Factor antibodyAnti-Gastric Intrinsic Factor antibodyAnti-Intrinsic Factor antibodyAnti-If antibodyAnti-Inf antibodyAnti-CBLIF antibodyAnti-GIF antibodyAnti-IFMH antibody |
Information sourced from Uniprot.org
