| Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. |
| Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
| Protein Name | Fad-Linked Sulfhydryl Oxidase AlrAugmenter Of Liver RegenerationHerv1Hepatopoietin |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Isoform 1: Mitochondrion Intermembrane SpaceMitochondrionIsoform 2: CytoplasmSecreted |
| Alternative Antibody Names | Anti-Fad-Linked Sulfhydryl Oxidase Alr antibodyAnti-Augmenter Of Liver Regeneration antibodyAnti-Herv1 antibodyAnti-Hepatopoietin antibodyAnti-GFER antibodyAnti-ALR antibodyAnti-HERV1 antibodyAnti-HPO antibody |
Information sourced from Uniprot.org
