Anti-GFER antibody (81-205) (STJ27416)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GFER (81-205) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFER |
| Gene ID | 2671 |
| Uniprot ID | ALR_HUMAN |
| Immunogen Region | 81-205 |
| Immunogen Sequence | MRTQQKRDTKFREDCPPDRE ELGRHSWAVLHTLAAYYPDL PTPEQQQDMAQFIHLFSKFY PCEECAEDLRKRLCRNHPDT RTRACFTQWLCHLHNEVNRK LGKPDFDCSKVDERWRDGWK DGSCD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 81-205 of human GFER (NP_005253.3). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. |
| Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
| Protein Name | Fad-Linked Sulfhydryl Oxidase AlrAugmenter Of Liver RegenerationHerv1Hepatopoietin |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Isoform 1: Mitochondrion Intermembrane SpaceMitochondrionIsoform 2: CytoplasmSecreted |
| Alternative Antibody Names | Anti-Fad-Linked Sulfhydryl Oxidase Alr antibodyAnti-Augmenter Of Liver Regeneration antibodyAnti-Herv1 antibodyAnti-Hepatopoietin antibodyAnti-GFER antibodyAnti-ALR antibodyAnti-HERV1 antibodyAnti-HPO antibody |
Information sourced from Uniprot.org