| Post Translational Modifications | Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity. |
| Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. |
| Protein Name | Geminin |
| Database Links | Reactome: R-HSA-68867Reactome: R-HSA-68962Reactome: R-HSA-69052 |
| Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic But Can Be Relocalized To The Nucleus |
| Alternative Antibody Names | Anti-Geminin antibodyAnti-GMNN antibody |
Information sourced from Uniprot.org
![Anti-Geminin antibody [EM6] (STJ16101743)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152249/347099/STJ16101743_1__33305.1681999364.jpg?c=1 "Anti-Geminin antibody [EM6] (STJ16101743)")
![Anti-Geminin antibody [EM6] (STJ16101743)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152249/347099/STJ16101743_1__33305.1681999364.jpg?c=1 "Anti-Geminin antibody [EM6] (STJ16101743)")
