Anti-Geminin antibody [EM6] (STJ16101743)

Anti-Geminin antibody [EM6] (STJ16101743)

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STJ16101743-1
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Short Description :Mouse monoclonal anti-Geminin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :EM6
Isotype:IgG2a
Conjugation:Unconjugated
Concentration:>=19 mg/L
Dilution Range:IHC-P 1:40
Formulation:Tissue culture supernatant with 15mM Sodium azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol:GMNN
Gene ID:51053
Uniprot ID:GEMI_HUMAN
Immunogen:A prokaryotic recombinant protein containing amino acids 5–209 of the mature protein.
Post Translational Modifications Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.
Function Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
Protein Name Geminin
Database Links Reactome: R-HSA-68867
Reactome: R-HSA-68962
Reactome: R-HSA-69052
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic But Can Be Relocalized To The Nucleus
Alternative Antibody Names Anti-Geminin antibody
Anti-GMNN antibody

Information sourced from Uniprot.org

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