• STJ72773 (1µg/ml) staining of Human Duodenum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Gelsolin-Isoform a antibody (N-Term) (STJ72773)

SKU:
STJ72773-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Gelsolin-Isoform a (N-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: GSN
Gene ID: 2934
Uniprot ID: GELS_HUMAN
Immunogen Region: N-Term
Accession Number: NP_000168.1; NP_937895.1; NP_001121138.1
Specificity: This antibody is expected to recognize isoform a (NP_000168.1) only. Reported variants represent identical protein: NP_001121138.1, NP_001121139.1 Reported variants represent identical protein: NP_001121135.1, NP_937895.1, NP_001121134.1, NP_00112113
Immunogen Sequence: PQGRVPEARPNS
Post Translational Modifications Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Protein Name Gelsolin
Agel
Actin-Depolymerizing Factor
Adf
Brevin
Database Links Reactome: R-HSA-264870
Reactome: R-HSA-6798695
Reactome: R-HSA-9662361
Reactome: R-HSA-977225
Cellular Localisation Isoform 2: Cytoplasm
Cytoskeleton
Isoform 1: Secreted
Alternative Antibody Names Anti-Gelsolin antibody
Anti-Agel antibody
Anti-Actin-Depolymerizing Factor antibody
Anti-Adf antibody
Anti-Brevin antibody
Anti-GSN antibody

Information sourced from Uniprot.org

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