Anti-Gelsolin-Isoform a antibody (N-Term) (STJ72773)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Gelsolin-Isoform a (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 100kDa band observed in Human Colon, Duodenum, Heart and Skeletal Muscle lysates (calculated MW of 85.7kDa according to NP_000168.1). Recommended concentration: 1-3µg/ml. Primar |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GSN |
| Gene ID | 2934 |
| Uniprot ID | GELS_HUMAN |
| Accession Number | NP_000168.1; NP_937895.1; NP_001121138.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | PQGRVPEARPNS |
| Specificity | This antibody is expected to recognize isoform a (NP_000168.1) only. Reported variants represent identical protein: NP_001121138.1, NP_001121139.1 Reported variants represent identical protein: NP_001121135.1, NP_937895.1, NP_001121134.1, NP_00112113 |
Additional Info
| Post Translational Modifications | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
| Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| Protein Name | GelsolinAgelActin-Depolymerizing FactorAdfBrevin |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6798695Reactome: R-HSA-9662361Reactome: R-HSA-977225 |
| Cellular Localisation | Isoform 2: CytoplasmCytoskeletonIsoform 1: Secreted |
| Alternative Antibody Names | Anti-Gelsolin antibodyAnti-Agel antibodyAnti-Actin-Depolymerizing Factor antibodyAnti-Adf antibodyAnti-Brevin antibodyAnti-GSN antibody |
Information sourced from Uniprot.org