| Host: |
Mouse |
| Applications: |
ELISA/WB/IF/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-GDNF is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3C1 |
| Conjugation: |
Unconjugated |
| Isotype: |
murine IgG1 |
| Formulation: |
PBS pH 7.4, with 0.1% sodium azide |
| Purification: |
Protein G purification |
| Dilution Range: |
ELISA 50 to 100 ng/ml; Western immunoblotting 2 to 5 µg/ml ; IF 2 to 10 µg/ml; IHC 5 µg/ml. Monoclonal antibody working amount has to be established practically for each particular antigen and assay format |
| Storage Instruction: |
Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles |
| Gene Symbol: |
GDNF |
| Gene ID: |
2668 |
| Uniprot ID: |
GDNF_HUMAN |
| Specificity: |
Human GDNF |
| Immunogen: |
Recombinant human GDNF protein produced using E. coli expression system. Human GDNF |
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Glial Cell Line-Derived Neurotrophic Factor antibodyAnti-Hgdnf antibodyAnti-Astrocyte-Derived Trophic Factor antibodyAnti-Atf antibodyAnti-GDNF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
