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Anti-GDNF antibody [3C1] (STJA0002911)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
Isotypemurine IgG1
ImmunogenRecombinant human GDNF protein produced using E. coli expression system. Human GDNF
General Information
| Short Description | Mouse monoclonal anti-GDNF for use in ELISA, WB, IF and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3C1 |
| Isotype | murine IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein G purification |
| Dilution Range | ELISA 50 to 100 ng/ml; Western immunoblotting 2 to 5 µg/ml ; IF 2 to 10 µg/ml; IHC 5 µg/ml. Monoclonal antibody working amount has to be established practically for each particular antigen and assay format |
| Formulation | PBS pH 7.4, with 0.1% sodium azide |
| Storage Instruction | Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles |
Target Information
| Gene Symbol | GDNF |
| Gene ID | 2668 |
| Uniprot ID | GDNF_HUMAN |
| Immunogen | Recombinant human GDNF protein produced using E. coli expression system. Human GDNF |
| Specificity | Human GDNF |
Additional Info
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Glial Cell Line-Derived Neurotrophic Factor antibodyAnti-Hgdnf antibodyAnti-Astrocyte-Derived Trophic Factor antibodyAnti-Atf antibodyAnti-GDNF antibody |
Information sourced from Uniprot.org