| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GDAP1 (1-225) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GDAP1 |
| Gene ID: |
54332 |
| Uniprot ID: |
GDAP1_HUMAN |
| Immunogen Region: |
1-225 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). |
| Immunogen Sequence: |
MRLNSTGEVPVLIHGENIIC EATQIIDYLEQTFLDERTPR LMPDKESMYYPRVQHYRELL DSLPMDAYTHGCILHPELTV DSMIPAYATTRIRSQIGNTE SELKKLAEENPDLQEAYIAK QKRLKSKLLDHDNVKYLKKI LDELEKVLDQVETELQRRNE ETPEEGQQPWLCGESFTLAD VSLAVTLHRLKFLGFARRNW GNGKRPNLETYYERVLKRKT FNKVL |
| Tissue Specificity | Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Regulates the mitochondrial network by promoting mitochondrial fission. |
| Protein Name | Ganglioside-Induced Differentiation-Associated Protein 1Gdap1 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Ganglioside-Induced Differentiation-Associated Protein 1 antibodyAnti-Gdap1 antibodyAnti-GDAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Catalasealase knockout (KO) HeLa cells, using [KO Validated] Catalase Rabbit polyclonal antibody (STJ119991) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98776/382824/STJ119991_1__14020.1713151324.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Catalasealase knockout (KO) HeLa cells, using [KO Validated] Catalase Rabbit polyclonal antibody (STJ119991) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
