Anti-GDAP1 antibody (1-225) (STJ28684)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GDAP1 (1-225) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GDAP1 |
| Gene ID | 54332 |
| Uniprot ID | GDAP1_HUMAN |
| Immunogen Region | 1-225 |
| Immunogen Sequence | MRLNSTGEVPVLIHGENIIC EATQIIDYLEQTFLDERTPR LMPDKESMYYPRVQHYRELL DSLPMDAYTHGCILHPELTV DSMIPAYATTRIRSQIGNTE SELKKLAEENPDLQEAYIAK QKRLKSKLLDHDNVKYLKKI LDELEKVLDQVETELQRRNE ETPEEGQQPWLCGESFTLAD VSLAVTLHRLKFLGFARRNW GNGKRPNLETYYERVLKRKT FNKVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). |
Additional Info
| Tissue Specificity | Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Regulates the mitochondrial network by promoting mitochondrial fission. |
| Protein Name | Ganglioside-Induced Differentiation-Associated Protein 1Gdap1 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Ganglioside-Induced Differentiation-Associated Protein 1 antibodyAnti-Gdap1 antibodyAnti-GDAP1 antibody |
Information sourced from Uniprot.org