Anti-GCSAM antibody (STJA0008760)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GCET2
General Information
| Short Description | Rabbit polyclonal anti-Germinal center-associated signaling and motility protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GCSAM |
| Gene ID | 257144 |
| Uniprot ID | GCSAM_HUMAN |
| Immunogen | Synthesized peptide derived from human GCET2 |
| Specificity | This antibody detects endogenous levels of GCET2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
| Protein Name | Germinal Center-Associated Signaling And Motility ProteinGerminal Center B-Cell-Expressed Transcript 2 ProteinGerminal Center-Associated Lymphoma ProteinHgal |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneIt Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6 |
| Alternative Antibody Names | Anti-Germinal Center-Associated Signaling And Motility Protein antibodyAnti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibodyAnti-Germinal Center-Associated Lymphoma Protein antibodyAnti-Hgal antibodyAnti-GCSAM antibodyAnti-GAL antibodyAnti-GCET2 antibody |
Information sourced from Uniprot.org