| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Germinal center-associated signaling and motility protein is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GCSAM |
| Gene ID: |
257144 |
| Uniprot ID: |
GCSAM_HUMAN |
| Specificity: |
This antibody detects endogenous levels of GCET2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human GCET2 |
| Post Translational Modifications | Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
| Protein Name | Germinal Center-Associated Signaling And Motility ProteinGerminal Center B-Cell-Expressed Transcript 2 ProteinGerminal Center-Associated Lymphoma ProteinHgal |
| Cellular Localisation | CytoplasmCell MembraneIt Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6 |
| Alternative Antibody Names | Anti-Germinal Center-Associated Signaling And Motility Protein antibodyAnti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibodyAnti-Germinal Center-Associated Lymphoma Protein antibodyAnti-Hgal antibodyAnti-GCSAM antibodyAnti-GAL antibodyAnti-GCET2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
