Anti-GCSAM antibody (STJA0008760)

SKU:
STJA0008760
€60.00 - €315.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Germinal center-associated signaling and motility protein is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GCSAM
Gene ID: 257144
Uniprot ID: GCSAM_HUMAN
Specificity: This antibody detects endogenous levels of GCET2 at Human, Mouse
Immunogen: Synthesized peptide derived from human GCET2
Post Translational Modifications Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation.
Function Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Protein Name Germinal Center-Associated Signaling And Motility Protein
Germinal Center B-Cell-Expressed Transcript 2 Protein
Germinal Center-Associated Lymphoma Protein
Hgal
Cellular Localisation Cytoplasm
Cell Membrane
It Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6
Alternative Antibody Names Anti-Germinal Center-Associated Signaling And Motility Protein antibody
Anti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibody
Anti-Germinal Center-Associated Lymphoma Protein antibody
Anti-Hgal antibody
Anti-GCSAM antibody
Anti-GAL antibody
Anti-GCET2 antibody

Information sourced from Uniprot.org

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