Anti-GATAD2B antibody (STJA0008240)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GATAD2B
General Information
| Short Description | Rabbit polyclonal anti-Transcriptional repressor p66-beta for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GATAD2B |
| Gene ID | 57459 |
| Uniprot ID | P66B_HUMAN |
| Immunogen | Synthesized peptide derived from human GATAD2B |
| Specificity | This antibody detects endogenous levels of GATAD2B at Human, Mouse |
Additional Info
| Function | Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. |
| Protein Name | Transcriptional Repressor P66-BetaGata Zinc Finger Domain-Containing Protein 2bP66/P68 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus SpeckleNucleusChromosomeSpeckled Nuclear Localization Requires Both Cr1 And Cr2 RegionsLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Transcriptional Repressor P66-Beta antibodyAnti-Gata Zinc Finger Domain-Containing Protein 2b antibodyAnti-P66/P68 antibodyAnti-GATAD2B antibodyAnti-KIAA1150 antibody |
Information sourced from Uniprot.org