Anti-Gamma-Tubulin antibody [SRM5139] (STJ11106968)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Gamma-Tubulin antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5139 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TUBG1 |
| Gene ID | 7283 |
| Uniprot ID | TBG1_HUMAN |
| Immunogen Sequence | LVSTIMSASTTTLRYPGYMN NDLIGLIASLIPTPRLHFLM TGYTPLTTDQSVASVRKTTV LDVMRRLLQPKNVMVSTGRD RQTNHCYIAILNIIQGEVDP TQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSA HRVSGLMMANHTSISSLFER TCRQYDKLRKREAFLEQFRK EDMFKDNFDEMDTSREIVQQ LIDEYHAATRPDYISWGTQE Q |
| Specificity | Recombinant protein of human Gamma-Tubulin. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome. |
| Function | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. |
| Protein Name | Tubulin Gamma-1 ChainGamma-1-TubulinGamma-Tubulin Complex Component 1Gcp-1 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleLocalizes To Mitotic Spindle Microtubules |
| Alternative Antibody Names | Anti-Tubulin Gamma-1 Chain antibodyAnti-Gamma-1-Tubulin antibodyAnti-Gamma-Tubulin Complex Component 1 antibodyAnti-Gcp-1 antibodyAnti-TUBG1 antibodyAnti-TUBG antibody |
Information sourced from Uniprot.org