| Post Translational Modifications | Palmitoylated by ZDHHC3/GODZ.required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses. Glycosylated. |
| Function | Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity.the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition. GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Gamma-2Gaba(A Receptor Subunit Gamma-2Gabaar Subunit Gamma-2 |
| Database Links | Reactome: R-RNO-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCell ProjectionDendriteCytoplasmic Vesicle MembraneThe Gamma-2 Subunits Are Present In Golgi Synapses And On The Extrasynaptic Membranes (When Associated With Alpha-1/6 And Beta-2/3 Subunits)And In Some Of The Mossy Fiber To Granule Cell Synapses (When Associated With Alpha-6 And Beta-2/3 Subunits)Present In Gabaergic And Glutamatergic Synapses On Granule Cells |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Gamma-2 antibodyAnti-Gaba(A Receptor Subunit Gamma-2 antibodyAnti-Gabaar Subunit Gamma-2 antibodyAnti-Gabrg2 antibody |
Information sourced from Uniprot.org
