• Western blot of rat brain lysate showing specific immunolabeling of the ~53 kDa Beta 3-subunit of the GABAA-R.
  • Immunofluorescence of mouse retina showing staining of GABAA-R, Beta 3-subunit (: STJA0003647, green, 1:300) and calbindin (red). The blue is DAPI staining nuclear DNA. Photo courtesy of Dr. Arlene Hirano, UCLA.
  • Western blot of rat cortical neurons showing specific immunolabeling of the ~53 kDa Beta 3-subunit of the GABAA-R (1:1000). Image kindly provided by Lidong Liu, University of British Columbia, Vancouver.

Anti-GABRB3 antibody (Cytoplasmic Loop) (STJA0003647)

SKU:
STJA0003647-100

£442.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABAA Receptor b3 (Cytoplasmic Loop) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC 1:300
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gabrb3
Gene ID: 24922
Uniprot ID: GBRB3_RAT
Immunogen Region: Cytoplasmic Loop
Immunogen: Fusion protein from the cytoplasmic loop of the beta 3 subunit.
Tissue Specificity Expressed in brain (at protein level).
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Beta-3
Gaba(A Receptor Subunit Beta-3
Database Links Reactome: R-RNO-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-3 antibody
Anti-Gaba(A Receptor Subunit Beta-3 antibody
Anti-Gabrb3 antibody
Anti-Gabrb-3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance