Anti-GABRB1 antibody (Cytoplasmic Loop) (STJA0003645)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein from the cytoplasmic loop of the beta 1 subunit.
General Information
| Short Description | Rabbit polyclonal anti-GABAA Receptor b1 (Cytoplasmic Loop) for use in WB in Mouse, Rat, Bovine, Canine, Chicken, Human, Non-Human Primates, Xenopus and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Xenopus/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Gabrb1 |
| Gene ID | 25450 |
| Uniprot ID | GBRB1_RAT |
| Immunogen | Fusion protein from the cytoplasmic loop of the beta 1 subunit. |
| Immunogen Region | Cytoplasmic Loop |
Additional Info
| Function | Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Beta-1Gaba(A Receptor Subunit Beta-1Gabaar Subunit Beta-1 |
| Database Links | Reactome: R-RNO-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-1 antibodyAnti-Gaba(A Receptor Subunit Beta-1 antibodyAnti-Gabaar Subunit Beta-1 antibodyAnti-Gabrb1 antibodyAnti-Gabrb-1 antibody |
Information sourced from Uniprot.org