Anti-GABRA3 antibody (N-Term) (STJA0003642)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the N-terminal region of the alpha 3 subunit.
General Information
| Short Description | Rabbit polyclonal anti-GABAA Receptor a 3 (N-Term) for use in WB and IHC in Mouse, Rat, Bovine, Canine, Human, Non-Human Primates and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Bovine/Canine/Human/Non-Human Primates/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from serum. |
| Dilution Range | WB 1:1000IHC 1:100 |
| Formulation | 100 ยตl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 ยตg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Gabra3 |
| Gene ID | 24947 |
| Uniprot ID | GBRA3_RAT |
| Immunogen | Synthetic peptide from the N-terminal region of the alpha 3 subunit. |
| Immunogen Region | N-Term |
Additional Info
| Tissue Specificity | Expressed in most brain regions. Expressed in lungs, in alveolar epithelium. |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-3Gaba(A Receptor Subunit Alpha-3Gabaar Subunit Alpha-3 |
| Database Links | Reactome: R-RNO-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 antibodyAnti-Gaba(A Receptor Subunit Alpha-3 antibodyAnti-Gabaar Subunit Alpha-3 antibodyAnti-Gabra3 antibodyAnti-Gabra-3 antibody |
Information sourced from Uniprot.org