| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fxyd Domain-Containing Ion Transport Regulator 3 (1-87) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FXYD3 |
| Gene ID: |
5349 |
| Uniprot ID: |
FXYD3_HUMAN |
| Immunogen Region: |
1-87 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human FXYD3 (NP_005962.1). |
| Immunogen Sequence: |
MQKVTLGLLVFLAGFPVLDA NDLEDKNSPFYYDWHSLQVG GLICAGVLCAMGIIIVMSAK CKCKFGQKSGHHPGETPPLI TPGSAQS |
| Tissue Specificity | Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level). |
| Post Translational Modifications | Glutathionylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 3Chloride Conductance Inducer Protein Mat-8Mammary Tumor 8 Kda ProteinPhospholemman-LikeSodium/Potassium-Transporting Atpase Subunit Fxyd3 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 3 antibodyAnti-Chloride Conductance Inducer Protein Mat-8 antibodyAnti-Mammary Tumor 8 Kda Protein antibodyAnti-Phospholemman-Like antibodyAnti-Sodium/Potassium-Transporting Atpase Subunit Fxyd3 antibodyAnti-FXYD3 antibodyAnti-MAT8 antibodyAnti-PLML antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
