| Tissue Specificity | Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level). |
| Post Translational Modifications | Glutathionylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 3Chloride Conductance Inducer Protein Mat-8Mammary Tumor 8 Kda ProteinPhospholemman-LikeSodium/Potassium-Transporting Atpase Subunit Fxyd3 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 3 antibodyAnti-Chloride Conductance Inducer Protein Mat-8 antibodyAnti-Mammary Tumor 8 Kda Protein antibodyAnti-Phospholemman-Like antibodyAnti-Sodium/Potassium-Transporting Atpase Subunit Fxyd3 antibodyAnti-FXYD3 antibodyAnti-MAT8 antibodyAnti-PLML antibody |
Information sourced from Uniprot.org
