Anti-FXYD3 antibody (1-87) (STJ11103957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Fxyd Domain-Containing Ion Transport Regulator 3 (1-87) antibody for use in IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FXYD3 |
| Gene ID | 5349 |
| Uniprot ID | FXYD3_HUMAN |
| Immunogen Region | 1-87 |
| Immunogen Sequence | MQKVTLGLLVFLAGFPVLDA NDLEDKNSPFYYDWHSLQVG GLICAGVLCAMGIIIVMSAK CKCKFGQKSGHHPGETPPLI TPGSAQS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human FXYD3 (NP_005962.1). |
Additional Info
| Tissue Specificity | Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level). |
| Post Translational Modifications | Glutathionylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 3Chloride Conductance Inducer Protein Mat-8Mammary Tumor 8 Kda ProteinPhospholemman-LikeSodium/Potassium-Transporting Atpase Subunit Fxyd3 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 3 antibodyAnti-Chloride Conductance Inducer Protein Mat-8 antibodyAnti-Mammary Tumor 8 Kda Protein antibodyAnti-Phospholemman-Like antibodyAnti-Sodium/Potassium-Transporting Atpase Subunit Fxyd3 antibodyAnti-FXYD3 antibodyAnti-MAT8 antibodyAnti-PLML antibody |
Information sourced from Uniprot.org