| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FUNDC1 (1-155) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FUNDC1 |
| Gene ID: |
139341 |
| Uniprot ID: |
FUND1_HUMAN |
| Immunogen Region: |
1-155 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-155 of human FUNDC1 (NP_776155.1). |
| Immunogen Sequence: |
MATRNPPPQDYESDDDSYEV LDLTEYARRHQWWNRVFGHS SGPMVEKYSVATQIVMGGVT GWCAGFLFQKVGKLAATAVG GGFLLLQIASHSGYVQIDWK RVEKDVNKAKRQIKKRANKA APEINNLIEEATEFIKQNIV ISSGFVGGFLLGLAS |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. |
| Function | Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. |
| Protein Name | Fun14 Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-8934903 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Fun14 Domain-Containing Protein 1 antibodyAnti-FUNDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ITCH knockout (KO) 293T cells, using [KO Validated] ITCH Rabbit polyclonal antibody (STJ118061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/96951/379801/STJ118061_1__34949.1713147667.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ITCH knockout (KO) 293T cells, using [KO Validated] ITCH Rabbit polyclonal antibody (STJ118061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")
