Anti-FTO antibody (1-349) (STJ11101469)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FTO (1-349) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Immunogen Region | 1-349 |
| Immunogen Sequence | MKPRQRKQYFRNMKRSDDSE REKRRKRRRLLQELGEQRIP YLSPTDPGFQDLWDSSYAGL ALRQSGTLPEGLHEKVQSAL LTLQRHGCLLRDLVRVRDRD VFTAVSRALVGQPGYTYRYL DTRLFTIPWHCEGEEGQKDE KGKPCCDSDLRDACKALWEL NQFFCSDVKQQTNARGVKRT RSDTENSEDAPGEGMCEEES VKDRLVEEKTIEEEEEDSGQ GCSHSSPPSSTPPAAQASL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of zebrafish FTO (XP_009301626.1). |
Additional Info
| Background | Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Human ortholog (s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). |
Information sourced from Uniprot.org