• STJ70382 (1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ70382 (1µg/ml) staining of Rat Lung lysate (35µg protein in RIPA buffer). Detected by chemiluminescence

Anti-FOXA2/HNF3B antibody (C-Term) (STJ70382)

SKU:
STJ70382-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-FOXA2/HNF3B (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-4-8µg/ml
ELISA-antibody detection limit dilution 1:4000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: FOXA2
Gene ID: 3170
Uniprot ID: FOXA2_HUMAN
Immunogen Region: C-Term
Accession Number: NP_068556.2; NP_710141.1
Specificity: This antibody is expected to recognise both reported isoforms: NP_068556.2; NP_710141.1
Immunogen Sequence: GVYSRPIMNSS
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Protein Name Hepatocyte Nuclear Factor 3-Beta
Hnf-3-Beta
Hnf-3b
Forkhead Box Protein A2
Transcription Factor 3b
Tcf-3b
Database Links Reactome: R-HSA-210745
Reactome: R-HSA-9796292
Reactome: R-HSA-9823730
Cellular Localisation Nucleus
Cytoplasm
Shuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent Manner
In Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus
Alternative Antibody Names Anti-Hepatocyte Nuclear Factor 3-Beta antibody
Anti-Hnf-3-Beta antibody
Anti-Hnf-3b antibody
Anti-Forkhead Box Protein A2 antibody
Anti-Transcription Factor 3b antibody
Anti-Tcf-3b antibody
Anti-FOXA2 antibody
Anti-HNF3B antibody
Anti-TCF3B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance