| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-FOXA2/HNF3B (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-4-8µg/mlELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FOXA2 |
| Gene ID: |
3170 |
| Uniprot ID: |
FOXA2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_068556.2; NP_710141.1 |
| Specificity: |
This antibody is expected to recognise both reported isoforms: NP_068556.2; NP_710141.1 |
| Immunogen Sequence: |
GVYSRPIMNSS |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Protein Name | Hepatocyte Nuclear Factor 3-BetaHnf-3-BetaHnf-3bForkhead Box Protein A2Transcription Factor 3bTcf-3b |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-9796292Reactome: R-HSA-9823730 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent MannerIn Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 3-Beta antibodyAnti-Hnf-3-Beta antibodyAnti-Hnf-3b antibodyAnti-Forkhead Box Protein A2 antibodyAnti-Transcription Factor 3b antibodyAnti-Tcf-3b antibodyAnti-FOXA2 antibodyAnti-HNF3B antibodyAnti-TCF3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
