Anti-FLNC antibody (335-385 aa) (STJ196198)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human FLNC at the amino acid range 335-385
General Information
| Short Description | Rabbit polyclonal anti-Filamin-C (335-385 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FLNC |
| Gene ID | 2318 |
| Uniprot ID | FLNC_HUMAN |
| Immunogen | Synthesized peptide derived from the human FLNC at the amino acid range 335-385 |
| Immunogen Region | 335-385 aa |
| Specificity | This antibody detects endogenous levels of FLNC at Human/Mouse |
Additional Info
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events. |
| Protein Name | Filamin-CFln-CFlncAbp-280-Like ProteinAbp-LActin-Binding-Like ProteinFilamin-2Gamma-Filamin |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoskeletonMyofibrilSarcomereZ LineA Small Amount Localizes At MembranesIn Striated Muscle CellsIt Predominantly Localizes In Myofibrillar Z LinesWhile A Minor Fraction Localizes With SubsarcolemmeTargeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert |
| Alternative Antibody Names | Anti-Filamin-C antibodyAnti-Fln-C antibodyAnti-Flnc antibodyAnti-Abp-280-Like Protein antibodyAnti-Abp-L antibodyAnti-Actin-Binding-Like Protein antibodyAnti-Filamin-2 antibodyAnti-Gamma-Filamin antibodyAnti-FLNC antibodyAnti-ABPL antibodyAnti-FLN2 antibody |
Information sourced from Uniprot.org