| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Filamin-C (335-385 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLNC |
| Gene ID: |
2318 |
| Uniprot ID: |
FLNC_HUMAN |
| Immunogen Region: |
335-385 aa |
| Specificity: |
This antibody detects endogenous levels of FLNC at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human FLNC at the amino acid range 335-385 |
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events. |
| Protein Name | Filamin-CFln-CFlncAbp-280-Like ProteinAbp-LActin-Binding-Like ProteinFilamin-2Gamma-Filamin |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoskeletonMyofibrilSarcomereZ LineA Small Amount Localizes At MembranesIn Striated Muscle CellsIt Predominantly Localizes In Myofibrillar Z LinesWhile A Minor Fraction Localizes With SubsarcolemmeTargeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert |
| Alternative Antibody Names | Anti-Filamin-C antibodyAnti-Fln-C antibodyAnti-Flnc antibodyAnti-Abp-280-Like Protein antibodyAnti-Abp-L antibodyAnti-Actin-Binding-Like Protein antibodyAnti-Filamin-2 antibodyAnti-Gamma-Filamin antibodyAnti-FLNC antibodyAnti-ABPL antibodyAnti-FLN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
