Anti-FLIP antibody (1-480aa) [AT8B12] (STJA0041491)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human FLIP (1-480aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-FLIP (1-480aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT8B12 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CFLAR |
| Gene ID | 8837 |
| Uniprot ID | CFLAR_HUMAN |
| Accession Number | NP_003870 |
| Immunogen | Recombinant human FLIP (1-480aa) purified from E. coli |
| Immunogen Region | 1-480aa |
Additional Info
| Tissue Specificity | Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle. |
| Post Translational Modifications | Proteolytically processed by CASP8 generating subunit p43 and p12. |
| Function | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
| Protein Name | Casp8 And Fadd-Like Apoptosis RegulatorCaspase HomologCashCaspase-Eight-Related ProteinCasperCaspase-Like Apoptosis Regulatory ProteinClarpCellular Flice-Like Inhibitory ProteinC-FlipFadd-Like Antiapoptotic Molecule 1Flame-1Inhibitor Of FliceI-FliceMach-Related Inducer Of ToxicityMritUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 |
| Database Links | Reactome: R-HSA-3371378 O15519-1Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357905 O15519-1Reactome: R-HSA-69416 O15519-2Reactome: R-HSA-75158 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Casp8 And Fadd-Like Apoptosis Regulator antibodyAnti-Caspase Homolog antibodyAnti-Cash antibodyAnti-Caspase-Eight-Related Protein antibodyAnti-Casper antibodyAnti-Caspase-Like Apoptosis Regulatory Protein antibodyAnti-Clarp antibodyAnti-Cellular Flice-Like Inhibitory Protein antibodyAnti-C-Flip antibodyAnti-Fadd-Like Antiapoptotic Molecule 1 antibodyAnti-Flame-1 antibodyAnti-Inhibitor Of Flice antibodyAnti-I-Flice antibodyAnti-Mach-Related Inducer Of Toxicity antibodyAnti-Mrit antibodyAnti-Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 antibodyAnti-CFLAR antibodyAnti-CASH antibodyAnti-CASP8AP1 antibodyAnti-CLARP antibodyAnti-MRIT antibody |
Information sourced from Uniprot.org