| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FKBP6 (1-327) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FKBP6 |
| Gene ID: |
8468 |
| Uniprot ID: |
FKBP6_HUMAN |
| Immunogen Region: |
1-327 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human FKBP6 (NP_003593.3). |
| Immunogen Sequence: |
MGGSALNQGVLEGDDAPGQS LYERLSQRMLDISGDRGVLK DVIREGAGDLVAPDASVLVK YSGYLEHMDRPFDSNYFRKT PRLMKLGEDITLWGMELGLL SMRRGELARFLFKPNYAYGT LGCPPLIPPNTTVLFEIELL DFLDCAESDKFCALSAEQQD QFPLQKVLKVAATEREFGNY LFRQNRFYDAKVRYKRALLL LRRRSAPPEEQHLVEAAKLP VLLNLSFTYLKLDRPTIAL |
| Tissue Specificity | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |
| Function | Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. |
| Protein Name | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6Inactive Ppiase Fkbp636 Kda Fk506-Binding Protein36 Kda FkbpFkbp-36Fk506-Binding Protein 6Fkbp-6Immunophilin Fkbp36 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmNucleusIn SpermatocytesIt Colocalizes With Piwil1 In Large Cytoplasmic GranulesDoes Not Localize To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 antibodyAnti-Inactive Ppiase Fkbp6 antibodyAnti-36 Kda Fk506-Binding Protein antibodyAnti-36 Kda Fkbp antibodyAnti-Fkbp-36 antibodyAnti-Fk506-Binding Protein 6 antibodyAnti-Fkbp-6 antibodyAnti-Immunophilin Fkbp36 antibodyAnti-FKBP6 antibodyAnti-FKBP36 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
