| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FKBP6 |
| Gene ID: | 8468 |
| Uniprot ID: | FKBP6_HUMAN |
| Immunogen Region: | 1-327 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human FKBP6 (NP_003593.3). |
| Immunogen Sequence: | MGGSALNQGVLEGDDAPGQS LYERLSQRMLDISGDRGVLK DVIREGAGDLVAPDASVLVK YSGYLEHMDRPFDSNYFRKT PRLMKLGEDITLWGMELGLL SMRRGELARFLFKPNYAYGT LGCPPLIPPNTTVLFEIELL DFLDCAESDKFCALSAEQQD QFPLQKVLKVAATEREFGNY LFRQNRFYDAKVRYKRALLL LRRRSAPPEEQHLVEAAKLP VLLNLSFTYLKLDRPTIAL |
| Tissue Specificity | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |
| Function | Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. |
| Protein Name | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 Inactive Ppiase Fkbp6 36 Kda Fk506-Binding Protein 36 Kda Fkbp Fkbp-36 Fk506-Binding Protein 6 Fkbp-6 Immunophilin Fkbp36 |
| Database Links | Reactome: R-HSA-1221632 Reactome: R-HSA-5601884 |
| Cellular Localisation | Cytoplasm Nucleus In Spermatocytes It Colocalizes With Piwil1 In Large Cytoplasmic Granules Does Not Localize To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 antibody Anti-Inactive Ppiase Fkbp6 antibody Anti-36 Kda Fk506-Binding Protein antibody Anti-36 Kda Fkbp antibody Anti-Fkbp-36 antibody Anti-Fk506-Binding Protein 6 antibody Anti-Fkbp-6 antibody Anti-Immunophilin Fkbp36 antibody Anti-FKBP6 antibody Anti-FKBP36 antibody |
Information sourced from Uniprot.org